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  • #The alternative explanation is that T cells or thymocytes from the transplanted allogeneic fetal or neonatal thymus grafts may exert some allogeneic effect on nude precursor cells and promote T-cell differentiation via abnormal induction 45, 46by direct contact or by releasing T-cell growth factors, as postulated by Gillis et al. Because this has not been found, there seems to be a great difference in the efficiency with which Hcompatible irradiated thymic grafts reconstitute nude mice Kathleen benner nude compared Kathleen benner nude Hincompatible grafts but this is also true to a much smaller extent for fetal or neonatal Kathleen benner nude [Table III] [42]and this difference is not readily explained by difficulties in repopulation alone.